Anti-BubR1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG41381.100	100 µl		-	-	6 - 14 business days*		624.00€

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Protein function: Essential component of the mitotic checkpoint. Required for normal mitosis... more

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Product information "Anti-BubR1"

Protein function: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. [The UniProt Consortium]

Keywords:	Anti-BUB1B, Anti-BUBR1, Anti-hBUBR1, EC=2.7.11.1, Anti-Protein SSK1, Anti-Mitotic checkpoint kinase MAD3L, Anti-MAD3/BUB1-related protein kinase, Anti-Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG41381

Properties

Application:	FC, IHC (paraffin), IP, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Synthetic peptide derived from Human BubR1
MW:	120 kD
Format:	Affinity Purified