Anti-BUB3

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA003601.25	25 µl		-		3 - 8 business days*		330.00€
ATA-HPA003601.100	100 µl		-		3 - 8 business days*		463.00€

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Protein function: Has a dual function in spindle-assembly checkpoint signaling and in promoting... more

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Product information "Anti-BUB3"

Protein function: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 99% and to rat: 99%

Keywords:	Anti-BUB3, Anti-Mitotic checkpoint protein BUB3
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA003601

Properties

Application:	ICC, IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: YQTRCIRAFP NKQGYVLSSI EGRVAVEYLD PSPEVQKKKY AFKCHRLKEN NIEQIYPVNA ISFHNIHNTF ATGGSDGFVN IWDPFNKKRL CQFHRYPTSI ASLAFSNDGT TLAIASSYMY EMDDTEHPED GIFIRQVTDA ETKPKSP (ATA-APrEST86555)