Anti-BTLA (human), clone 6F4

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
AG-20B-0049-C100	100 µg		-		3 - 9 business days*		413.00€

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B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic... more

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Product information "Anti-BTLA (human), clone 6F4"

B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory cosignaling function of HVEM.

Keywords:	Anti-Btla, Anti-CD272, Anti-B- and T-lymphocyte attenuator, Anti-B- and T-lymphocyte-associated protein
Supplier:	AdipoGen Life Sciences
Supplier-Nr:	AG-20B-0049

Properties

Application:	FC, ELISA
Antibody Type:	Monoclonal
Clone:	6F4
Conjugate:	No
Host:	Rat
Species reactivity:	human
Immunogen:	Ectodomain of human BTLA fused to human IgG Fc
Format:	Affinity Purified