Anti-BST2 / Bone marrow stromal antigen 2, clone BST2/13681R

1 mg/ml in 1X PBS, BSA free, sodium azide free. BST2 antibody, also known as Bone marrow stromal antigen 2 antibody, recognizes Tetherin, an interferon-inducible antiviral restriction factor encoded by the human BST2 gene located on chromosome 19p13.2. BST2 is a type II transmembrane protein that localizes to the plasma membrane, endosomes, and the trans-Golgi network. It is widely referred to in the literature as Tetherin, CD317, and HM1.24. BST2 antibody is commonly used in research investigating innate immune responses, viral restriction mechanisms, and interferon signaling pathways.Bone marrow stromal antigen 2 possesses a short N-terminal cytoplasmic tail, a single-pass transmembrane domain, an extracellular coiled-coil region, and a C-terminal glycosylphosphatidylinositol anchor. This unusual dual-anchor topology enables Tetherin to physically tether budding virions to the cell surface, thereby preventing viral particle release. BST2 expression is strongly induced by type I interferons, linking its function to antiviral defense pathways. BST2 antibody supports investigation of host-virus interactions and mechanisms of viral restriction.BST2 is broadly expressed in immune cell populations including B lymphocytes, plasmacytoid dendritic cells, activated T cells, and monocytes. Expression is also observed in epithelial tissues during inflammatory responses. Tetherin has been extensively studied in the context of HIV-1 infection, where viral proteins such as Vpu antagonize BST2 to promote viral release. In addition to its antiviral role, CD317 has been implicated in NF-kappaB signaling and regulation of cytokine production, highlighting its broader involvement in immune signaling networks.Beyond infectious disease research, BST2 expression has been reported in multiple myeloma and other hematologic malignancies, where it serves as a surface marker in research settings. Clone BST2/13681R is a recombinant rabbit monoclonal antibody developed to recognize BST2 for research applications. This antibody targets Bone marrow stromal antigen 2 in research settings and supports studies of antiviral defense, interferon biology, and immune regulation.