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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
600-401-Z91 | 100 µg | - | - |
6 - 10 business days* |
684.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Anti-BRSK1 Antibody was affinity purified from monospecific antiserum by immunoaffinity... more
Product information "Anti-BRSK1"
Anti-BRSK1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with BRSK1 from other sources has not been determined. Protein function: Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma- tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. [The UniProt Consortium]
Keywords: | Anti-BRSK1, Anti-hSAD1, Anti-KIAA1811, EC=2.7.11.1, Anti-SAD1 homolog, EC=2.7.11.26, Anti-Brain-selective kinase 1, Anti-BR serine/threonine-protein kinase 1, Anti-Serine/threonine-protein kinase SAD-B, Anti-Serine/threonine-protein kinase BRSK1, Anti-Syn |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 600-401-Z91 |
Properties
Application: | ELISA, IHC, IFM, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | 28 amino acid synthetic peptide from near the C-terminus of human BRSK1. |
Format: | Purified |
Database Information
KEGG ID : | K08796 | Matching products |
UniProt ID : | Q8TDC3 | Matching products |
Gene ID | GeneID 84446 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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