Anti-BRD7

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A302-304A-T	10 µl (10 µg)		-		2 - 8 business days*		178.00€
A302-304A	100 µl (100 µg)		-		2 - 8 business days*		630.00€

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Protein function: Acts both as coactivator and as corepressor. May play a role in chromatin... more

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Product information "Anti-BRD7"

Protein function: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. [The UniProt Consortium]

Keywords:	Anti-BRD7, Anti-BP75, Anti-Protein CELTIX-1, Anti-75 kDa bromodomain protein, Anti-Bromodomain-containing protein 7
Supplier:	Bethyl Laboratories
Supplier-Nr:	A302-304A

Properties

Application:	WB, IP, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: orangutan)
Immunogen:	synthetic peptide. The epitope recognized by A302-304A-T maps to a region between residue 601 and 651 of human bromodomain containing 7 using the numbering given in entry NP_037395.2 (GeneID 29117).
Format:	Antigen Affinity Purified