Anti-BRCA1 (IHC)

Anti-BRCA1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00278-T 10 µl (5+ slides) -

3 - 9 business days

125.00€
IHC-00278 100 µl (50+ slides) -

3 - 9 business days

456.00€
 
Protein function: E3 ubiquitin-protein ligase that specifically mediates the formation of... more
Product information "Anti-BRCA1 (IHC)"
Protein function: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator (PubMed:20160719). [The UniProt Consortium]
Keywords: Anti-BRCA1, Anti-RNF53, Anti-RING finger protein 53, Anti-RING-type E3 ubiquitin transferase BRCA1, Anti-Breast cancer type 1 susceptibility protein
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00278-T

Properties

Application: IHC, IHC-IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Gorilla, Chimpanzee, Long-haired Spider Monkey, Brown-headed Spider Monkey, Agile Gibbon, Bornean Orangutan, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00278 maps to a region between residue 700 and 750 of human breast cancer 1 using the numbering given in entry NP_009225.1 (GeneID 672).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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