Anti-BRCA1 (Breast Marker), clone BRCA1/1398

Anti-BRCA1 (Breast Marker), clone BRCA1/1398
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3240SAF-100UG 100 µg - -

3 - 10 business days*

752.00€
 
1 mg/ml in 1X PBS, BSA free, sodium azide free. BRCA1 (Breast cancer type 1 susceptibility... more
Product information "Anti-BRCA1 (Breast Marker), clone BRCA1/1398"
1 mg/ml in 1X PBS, BSA free, sodium azide free. BRCA1 (Breast cancer type 1 susceptibility protein) is a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Protein function: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator (PubMed:20160719). [The UniProt Consortium]
Keywords: Anti-BRCA1, Anti-RNF53, Anti-RING finger protein 53, Anti-RING-type E3 ubiquitin transferase BRCA1, Anti-Breast cancer type 1 susceptibility protein, BRCA1 Antibody (Breast Marker)
Supplier: NSJ Bioreagents
Supplier-Nr: V3240SAF

Properties

Application: FC, IF, IHC (paraffin)
Antibody Type: Monoclonal
Clone: BRCA1/1398
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Amino acids 445-620 were used as the immunogen for the BRCA1 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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