Anti-BRAP Magnetic Beads

Formulation: Supplied as solution in phosphate buffered saline containing 0.01% BSA and 0.02% sodium azide. Bead diameter: 0.5 µm. Antigen ID: ABS-PP-6256. Core Sequence: MKTKFKETIE KCDNLEHKLN DLLKEKQSVE RKCTQLNTKV AKLTNELKEE QEMNKCLRAN QVLLQNKLKE EERVLKETCD QKDLQITEIQ EQLRDVMFYL ETQQKINHLP AETRQEIQEG QINIAMASAS SPASSGGSGK LPSRKGRSKR. Homologies: Highest antigen sequence identity to the following orthologs: Mouse - 85%, Pig - 94%, Cynomolgus monkey - 99% Protein Function: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport [The Uniprot Consortium]