Anti-BNIP3

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG58336.100	100 µl		-	-	6 - 14 business days*		707.00€

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Protein function: Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role... more

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Product information "Anti-BNIP3"

Protein function: Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. [The UniProt Consortium]

Keywords:	Anti-NIP3, Anti-BNIP3, Anti-BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG58336

Properties

Application:	ICC, IF, IHC (paraffin), WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Recombinant funsion protein corresponding to aa. 1-140 of Human BNIP3 (NP_004043.3)
MW:	27 kD
Format:	Affinity Purified