Anti-BMPR2

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F47742-0.08ML 80 µl - -

3 - 10 business days*

326.00€
NSJ-F47742-0.4ML 400 µl - -

3 - 10 business days*

702.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. BMPR2 is a member of the bone morphogenetic protein... more
Product information "Anti-BMPR2"
In 1X PBS, pH 7.4, with 0.09% sodium azide. BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension. Protein function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. [The UniProt Consortium]
Keywords: Anti-PPH1, Anti-BMPR2, Anti-BMPR-2, Anti-BMPR-II, EC=2.7.11.30, Anti-BMP type-2 receptor, Anti-BMP type II receptor, Anti-Bone morphogenetic protein receptor type-2, Anti-Bone morphogenetic protein receptor type II, BMPR2 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: F47742

Properties

Application: IHC, FC, WB, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A portion of amino acids 28-59 from the human protein
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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