Anti-BIRC6 (BRUCE, KIAA1289, Baculoviral IAP repeat-containing 6, Apollon)

BIRC6 is a member of a family of proteins that inhibit apoptosis, likely through interference with activation of ICE-like proteases. BIRC6 which contains a single BIR domain and a ubiquitin-conjugating enzyme domain, is expressed in multiple cancer cell lines. Brain cancer cell lines that overexpress BIRC6 demonstrate multi-drug resistanceimplying that BIRC6 may protect cancer cells from undergoing apoptosis and participate in tumorigenesis and drug resistance. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:16000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.