Anti-BiP / GRP78

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG57717.100	100 µl		-	-	6 - 14 business days*		658.00€

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Protein function: Endoplasmic reticulum chaperone that plays a key role in protein folding and... more

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Product information "Anti-BiP / GRP78"

Protein function: Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate. Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958, PubMed:19538957). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1. [The UniProt Consortium]

Keywords:	Anti-BiP, Anti-GRP-78, Anti-HSP70 family protein 5, Anti-Binding-immunoglobulin protein, Anti-78 kDa glucose-regulated protein, Anti-Endoplasmic reticulum chaperone BiP, Anti-Heat shock protein family A member 5
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG57717

Properties

Application:	ICC, IF, IP, WB
Antibody Type:	Monoclonal
Conjugate:	No
Host:	Mouse
Species reactivity:	human, mouse, rat
Immunogen:	Purified recombinant Human BiP / GRP78 protein expressed in E. coli
Format:	Affinity Purified