Anti-Beta-mammal/insect toxin Ts1

Make to order. Production time: 70-80 business days. Deliverables: 1. 200 µg antigen (used as positive control), 2. 1 ml pre-immune serum (used as negative control) , 3. Rabbit polyclonal antibody, antigen affinity purified. Quality Guarantee: 1. Antibody purity > 90% confirmed by SDS-PAGE, 2. Antibody titer > 1: 64,000 confirmed by ELISA, 3. WB positive with the immunogen protein (not applicable for synthetic peptide). Applications: ELISA, WB (positive for the recombinant immunogen protein/peptide). Buffer: Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4. Protein function: Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable) (PubMed:25862296). Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements (PubMed:17698594, PubMed:19005548). Depending on Nav channel subtypes tested, can also bind Nav domains DIII (low affinity) and DIV (very low affinity) (PubMed:17698594, PubMed:19005548, PubMed:25624450). Acts on almost all the Nav channels tested (mammalian Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.9/SCN11A, and insect DmNav1) (PubMed:17698594, PubMed:21670206, PubMed:24989851, PubMed:25862296, PubMed:31012002, PubMed:9048656). Is highly active against both mammals and insects (PubMed:17118417, PubMed:21549737). Irreversibly modulates DmNav channels (PubMed:25862296). Other Ts1 activities have been studied, such as immunomodulation, antimicrobial activity or exocrine secretion (Probable). This toxin exhibits an antifungal activity against filamentous fungi (PubMed:28634472). In vitro, it has an important immunomodulatory effect on macrophages by stimulating the release of pro-inflammatory cytokines (PubMed:21549737). It also shows an activity in exocrine secretion in pancreas, stomach and adrenal gland (PubMed:10347806, PubMed:1993690, PubMed:9611141). [The UniProt Consortium]