Anti-beta Catenin, clone 1F6

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG40560.50 50 µg - -

6 - 14 business days*

520.00€
 
Protein function: Key downstream component of the canonical Wnt signaling pathway. In the absence... more
Product information "Anti-beta Catenin, clone 1F6"
Protein function: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E- cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. [The UniProt Consortium]
Keywords: Anti-CTNNB, Anti-CTNNB1, Anti-Beta-catenin, Anti-Catenin beta-1
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG40560

Properties

Application: FC, ICC, IHC (paraffin), WB
Antibody Type: Monoclonal
Clone: 1F6
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Recombinant protein corresponding to A2-K233 of Human beta Catenin
MW: 85 kD
Format: Antigen Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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