Anti-Beta-2 Microglobulin (Renal Failure & Tumor Marker), clone SPM617

Formulation: Purified Ab WITHOUT BSA and Azide at 1.0mg/ml. Cellular Localization: Cell surface, Secreted. Positive Control: Cervix, Endometrial, HL-60 or HeLa cells. Melanomas and Lymphoma. Carcinoma of Stomach, Kidney or Colon. Chromosome Location: 15q21-q22.2. Protein Function: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553) [The Uniprot Consortium]