Anti-BAZ2A / TIP5

Anti-BAZ2A / TIP5
Item number Size Datasheet Manual SDS Delivery time Quantity Price
G-CAB17629.20 20 µl -

9 - 20 business days*

149.00€
 
Protein function: Essential component of the NoRC (nucleolar remodeling complex) complex, a... more
Product information "Anti-BAZ2A / TIP5"
Protein function: Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter, pRNA-binding is required for heterochromatin formation and rDNA silencing. [The UniProt Consortium]
Keywords: Anti-Tip5, Anti-BAZ2A, Anti-hWALp3, Anti-KIAA0314, Anti-TTF-I-interacting protein 5, Anti-Bromodomain adjacent to zinc finger domain protein 2A, Anti-Transcription termination factor I-interacting protein 5
Supplier: Assay Genie
Supplier-Nr: CAB17629

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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