Anti-Axl

Anti-Axl
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-167A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-167A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-167A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix... more
Product information "Anti-Axl"
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3, but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. [The UniProt Consortium]
Keywords: Anti-UFO, Anti-AXL, EC=2.7.10.1, Anti-AXL oncogene, Anti-Tyrosine-protein kinase receptor UFO
Supplier: Bethyl Laboratories
Supplier-Nr: A302-167A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Gorilla)
Immunogen: synthetic peptide. The epitope recognized by A302-167A-T maps to a region between residue 250 and 300 of human AXL receptor tyrosine kinase using the numbering given in entry NP_068713.2 (GeneID 558).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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