Anti-Atg9a

function:Plays a role in autophagy.,similarity:Belongs to the ATG9 family., Protein function: Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed:27510922, PubMed:29437695, PubMed:32513819, PubMed:33468622, PubMed:33850023, PubMed:32610138, PubMed:33106659). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:16940348, PubMed:22456507, PubMed:33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:33106659). Also required to supply phosphatidylinositol 4- phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (PubMed:30917996). In addition to autophagy, also plays a role in necrotic cell death. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000, ELISA 1:10000-20000. Cellular localization: Preautophagosomal structure membrane , Multi-pass membrane protein . Cytoplasmic vesicle, autophagosome membrane , Multi-pass membrane protein . Golgi apparatus, trans-Golgi network membrane , Multi-pass membrane protein . Late endosome membrane , Multi-pass membrane protein . Recycling endosome membrane , Multi-pass membrane protein . Endoplasmic reticulum membrane , Multi-pass membrane protein . Mitochondrion membrane , Multi-pass membrane protein . Mainly localizes to the trans-Golgi network (TGN) and the endosomal system, cycles between them though vesicle trafficking (PubMed:27316455, PubMed:27663665). Export from the TGN to promote formation of autophagosomes is mediated by the AP-4 complex (PubMed:29180427, PubMed:30262884). Under amino acid starvation or rapamycin treatment, redist