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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
600-401-Y81 | 100 µg | - | - |
6 - 10 business days* |
684.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Anti-ATG3 Antibody was affinity purified from monospecific antiserum by immunoaffinity... more
Product information "Anti-ATG3"
Anti-ATG3 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with ATG3 from other sources has not been determined. Protein function: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12- ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. [The UniProt Consortium]
Keywords: | Anti-ATG3, Anti-APG3, Anti-hApg3, Anti-APG3-like, EC=6.3.2.-, Anti-Protein PC3-96, Anti-Autophagy-related protein 3, Anti-Ubiquitin-like-conjugating enzyme ATG3 |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 600-401-Y81 |
Properties
Application: | ELISA, IHC, IFM, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | 18 amino acid synthetic peptide near the internal region of human ATG3. |
Format: | Purified |
Database Information
KEGG ID : | K08343 | Matching products |
UniProt ID : | Q9NT62 | Matching products |
Gene ID | GeneID 64422 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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