Protein function: Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2- driven inflammatory cytokine response (PubMed:24238340). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). [The UniProt Consortium]
Anti-APG16L, Anti-ATG16L1, Anti-APG16-like 1, Anti-Autophagy-related protein 16-1
synthetic peptide. The epitope recognized by A303-295A-T maps to a region between residue 300 and 350 of human ATG16 Autophagy Related 16-like 1 using the numbering given in entry NP_110430.5 (GeneID 55054).