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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
200-303-W61 | 100 µg | - | - |
6 - 10 business days* |
713.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Anti-ATF4 Antibody was purified from concentrated tissue culture supernate by Protein G... more
Product information "Anti-ATF4, clone S360A-24, Peroxidase Conjugated"
Anti-ATF4 Antibody was purified from concentrated tissue culture supernate by Protein G chromatography. BLAST analysis suggests that it is 85% identical to mouse, 86% identical to rat and <50% identical to ATF5. Will not cross react with ATF5. Protein function: Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. [The UniProt Consortium]
Keywords: | Anti-ATF4, Anti-CREB2, Anti-CREB-2, Anti-TaxREB67, Anti-DNA-binding protein TAXREB67, Anti-Activating transcription factor 4, Anti-cAMP-responsive element-binding protein 2, Anti-cAMP-dependent transcription factor ATF-4, Anti-Cyclic AMP-dependent transcr |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 200-303-W61 |
Properties
Application: | ELISA, IHC, WB |
Antibody Type: | Monoclonal |
Clone: | S360A-24 |
Conjugate: | HRP |
Host: | Mouse |
Species reactivity: | human, rat |
Immunogen: | Fusion protein containing amino acids 25-327 of human ATF4. |
Format: | Purified |
Database Information
KEGG ID : | K04374 | Matching products |
UniProt ID : | P18848 | Matching products |
Gene ID | GeneID 468 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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