Anti-ATF2

Anti-ATF2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-649A-T 10 µl (10 µg) -

3 - 9 business days

125.00€
A301-649A 100 µl (100 µg) -

3 - 9 business days

443.00€
 
Protein function: Transcriptional activator which regulates the transcription of various genes,... more
Product information "Anti-ATF2"
Protein function: Transcriptional activator which regulates the transcription of various genes, including those involved in anti- apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. [The UniProt Consortium]
Keywords: Anti-ATF2, Anti-HB16, Anti-CREB2, Anti-CREB-2, Anti-Histone acetyltransferase ATF2, Anti-Activating transcription factor 2, Anti-cAMP-dependent transcription factor ATF-2, Anti-cAMP-responsive element-binding protein 2
Supplier: Bethyl Laboratories
Supplier-Nr: A301-649A-T

Properties

Application: IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse)
Immunogen: synthetic peptide. The epitope recognized by A301-649A-T maps to a region between residue 250 and 300 of human activating transcription factor 2 using the numbering given in entry AAY17203.1 (GeneID 1386).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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