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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A302-053A | 100 µl (100 µg) | - |
2 - 8 business days* |
588.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Plays a role in preventing exon skipping, ensuring the accuracy of splicing and... more
Product information "Anti-ASF"
Protein function: Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'- CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. [The UniProt Consortium]
Keywords: | Anti-ASF, Anti-ASF-1, Anti-SRSF1, Anti-Alternative-splicing factor 1, Anti-Serine/arginine-rich splicing factor 1, Anti-Splicing factor, arginine/serine-rich 1, Anti-pre-mRNA-splicing factor SF2, P33 subunit |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A302-053A |
Properties
Application: | WB, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: mouse, zebrafish, X. tropicalis, bovine, pig, orangutan) |
Immunogen: | synthetic peptide. The epitope recognized by A302-053A maps to a region between residue 198 and 248 of human alternative splicing factor (splicing factor, arginine/serine-rich 1) using the numbering given in entry NP_008855.1 (GeneID 6426). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K12890 | Matching products |
UniProt ID : | Q07955 | Matching products |
Gene ID | GeneID 6426 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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