Anti-ASCL2 / Achaete-scute homolog 2

In 1X PBS, pH 7.4, with 0.09% sodium azide. ASCL2 belongs to a family of genes that are involved in determining cell fate and differentiation, particularly in the development of tissues such as the nervous system and the intestines. Studies have shown that ASCL2 plays a critical role in regulating the self-renewal and differentiation of stem cells, making it a key player in tissue regeneration and repair processes. One of the most fascinating aspects of ASCL2 is its ability to control the expression of other genes, essentially acting as a master regulator in the cellular development process. By activating or repressing specific genes, ASCL2 can influence the fate of a cell and dictate its ultimate function within a tissue or organ. ASCL2 has been implicated in a variety of diseases and conditions, including certain types of cancers where its dysregulation can lead to uncontrolled cell growth and proliferation. Protein function: [Gasdermin-A]: This form constitutes the precursor of the pore-forming protein and acts as a sensor of infection: upon infection by S.pyogenes, specifically cleaved by S.pyogenes effector protein SpeB in epithelial cells, releasing the N-terminal moiety (Gasdermin-A, N- terminal) that binds to membranes and forms pores, triggering pyroptosis. [The UniProt Consortium]