Anti-ASCL1

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-12280.20 20 µl -

7 - 16 business days*

71.00€
E-AB-12280.60 60 µl -

7 - 16 business days*

143.00€
E-AB-12280.120 120 µl -

7 - 16 business days*

238.00€
E-AB-12280.200 200 µl -

7 - 16 business days*

396.00€
 
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors.... more
Product information "Anti-ASCL1"
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. Protein function: Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. [The UniProt Consortium]
Keywords: Anti-ASH-1, Anti-hASH1, Anti-bHLHa46, Anti-Achaete-scute homolog 1, Anti-Class A basic helix-loop-helix protein 46, ASCL1 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-12280

Properties

Application: IHC, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Synthetic peptide of human ASCL1
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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