Anti-Arrdc1

similarity:Belongs to the arrestin family., Protein function: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940). [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.. Cellular localization: Cell membrane . Also found in extracellular vesicles different from exosomes. .