Anti-ARL2 / ADP-ribosylation factor-like protein 2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. ARL2 antibody detects ADP-ribosylation factor-like protein 2, a small GTP-binding protein involved in microtubule dynamics, mitochondrial function, and intracellular transport. Encoded by the ARL2 gene on chromosome 11q13.2, this evolutionarily conserved member of the ARF family of GTPases cycles between active GTP-bound and inactive GDP-bound states to regulate cytoskeletal organization and vesicle trafficking. ARL2 participates in essential cellular processes ranging from ciliary assembly to energy metabolism.Structurally, ARL2 is a 184-amino-acid cytosolic protein of approximately 21 kilodaltons containing the characteristic GTP-binding motifs (G1-G5 boxes) required for nucleotide exchange and hydrolysis. It interacts with cofactors such as cofactor D (TBCD) and cofactor E (TBCE) to modulate tubulin folding and polymerization. ARL2 localizes to both cytoplasm and mitochondria, where it forms complexes that support microtubule stability and mitochondrial fusion.The ARL2 antibody is widely used in cell biology, neurobiology, and mitochondrial research to study small GTPase signaling, cytoskeletal organization, and intracellular trafficking. Western blot analysis detects a 21 kilodalton band corresponding to ARL2, while immunofluorescence demonstrates cytoplasmic and mitochondrial staining patterns. This antibody provides a dependable tool for monitoring ARL2-mediated control of tubulin dynamics and organelle function.Functionally, ARL2 regulates the folding of alpha and beta tubulin heterodimers, supporting microtubule assembly critical for intracellular transport and cell division. Within mitochondria, ARL2 influences fusion, morphology, and ATP production by interacting with proteins such as ANT1 and ELMOD2. Dysregulation of ARL2 expression affects mitochondrial integrity, axonal transport, and cell viability. In neurons, ARL2 contributes to microtubule-based trafficking of synaptic vesicles and organelles. The ARL2 antibody enables analysis of these processes and provides insights into cytoskeletal and metabolic coordination. NSJ Bioreagents validates this antibody for its applications, ensuring reliable and sensitive detection for GTPase and mitochondrial studies.