Anti-Annexin A1, clone YN00086m

Annexin A1 is a member of calcium dependent phospholipid binding protein superfamily, which is widely expresseded in human tissues. It is an endogenous anti-inflammatory medium, which plays a role in innate and adaptive immunity by controlling the biosynthesis of inflammation, prostaglandin and leukotriene mediators. Annexin A1 can be used to distinguish leukemia from other B-cell lymphoma. The overexpression of Annexin A1 is also frequently found in adenocarcinoma of the esophageal and gastroesophageal junction, which is related to pathological T stage and distal metastasis, and is an independent prognostic indicator. Protein function: Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions. Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton. [The UniProt Consortium]