Anti-ANKRD1 / Ankyrin repeat domain-containing protein 1

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. ANKRD1 antibody detects Ankyrin repeat domain-containing protein 1, encoded by the ANKRD1 gene. Ankyrin repeat domain-containing protein 1 is a transcriptional cofactor and stress-responsive protein that contributes to cardiac muscle biology, mechanical signaling, and gene regulation. ANKRD1 antibody provides researchers with a highly specific reagent for studying cardiomyocyte adaptation, hypertrophy, and muscle stress responses.Ankyrin repeat domain-containing protein 1 belongs to the CARP (cardiac ankyrin repeat protein) family. Research using ANKRD1 antibody has shown that it is predominantly expressed in heart and skeletal muscle, where it localizes to the sarcomere, especially the I-band. Its ankyrin repeat domains allow it to interact with titin, myopalladin, and transcriptional regulators, linking mechanical stretch sensing to gene expression programs. This dual localization to sarcomeres and nuclei makes it an important signaling intermediary.Studies with ANKRD1 antibody have revealed that its expression is induced by hypertrophic stress, hypoxia, and injury. In cardiomyocytes, ANKRD1 acts as both a structural stabilizer and a regulator of stress-induced transcriptional pathways. Elevated expression has been observed in dilated and hypertrophic cardiomyopathy, suggesting its potential role as a biomarker of heart disease.Dysregulation of ANKRD1 has also been associated with muscular disorders and cancer. Research using ANKRD1 antibody has demonstrated that mutations in ANKRD1 contribute to congenital cardiomyopathy, while altered expression in tumors influences cell proliferation and invasion. Its pleiotropic functions in muscle and non-muscle tissues highlight its importance across biology.ANKRD1 antibody is widely applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies expression in cardiac and skeletal tissue, immunohistochemistry highlights localization in diseased myocardium, and immunofluorescence demonstrates sarcomeric localization in cardiomyocytes. These methods make ANKRD1 antibody indispensable for cardiac biology research.By supplying validated ANKRD1 antibody reagents, NSJ Bioreagents supports studies into sarcomere biology, transcriptional regulation, and disease. Detection of Ankyrin repeat domain-containing protein 1 provides researchers with insight into how cardiomyocytes adapt to stress and maintain function.