Anti-AMACR / p504S (Prostate Cancer Marker), clone AMACR/2748R

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V7480IHC-7ML 7 ml - -

3 - 10 business days*

752.00€
 
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*.... more
Product information "Anti-AMACR / p504S (Prostate Cancer Marker), clone AMACR/2748R"
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*. This antibody recognizes a protein of 43kDa, which is identified as AMACR, also known as p504S. It is an enzyme that is involved in bile acid biosynthesis and -oxidation of branched-chain fatty acids. AMACR is essential in lipid metabolism. It is expressed in cells of premalignant high-grade prostatic intraepithelial neoplasia (HGPIN) and prostate adenocarcinoma. The majority of the carcinoma cells show a distinct granular cytoplasmic staining reaction. AMACR is present at low or undetectable levels in glandular epithelial cells of normal prostate and benign prostatic hyperplasia. A spotty granular cytoplasmic staining is seen in a few cells of the benign glands. AMACR is expressed in normal liver (hepatocytes), kidney (tubular epithelial cells) and gall bladder (epithelial cells). Expression has also been found in lung (bronchial epithelial cells) and colon (colonic surface epithelium). AMACR expression can also be found in hepatocellular carcinoma and kidney carcinoma. Past studies have also shown that AMACR is expressed in various colon carcinomas (well, moderately and poorly differentiated) and over expressed in prostate carcinoma. Protein function: Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers. [The UniProt Consortium]
Keywords: Anti-AMACR, EC=5.1.99.4, Anti-2-methylacyl-CoA racemase, Anti-Alpha-methylacyl-CoA racemase, AMACR / p504S Antibody (Prostate Cancer Marker)
Supplier: NSJ Bioreagents
Supplier-Nr: V7480IHC

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: AMACR/2748R
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A portion of amino acids 297-394
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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