Anti-AMACR/p504s, clone YN00066m

Alpha-methylacyl-CoA racemase (AMACR), also known as P504S, is a mitochondrial and peroxisome enzyme. AMACR is expressed in normal liver (hepatocyte), kidney (tubular epithelial cell) and gallbladder (epithelial cell). AMACR is also expressed in Lung (bronchial epithelial cells) and colon (surface epithelium of colon). AMACR is a specific marker of prostate cancer. Protein function: Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:7649182, PubMed:10655068, PubMed:11060359). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2- (4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:7649182, PubMed:10655068, PubMed:11060359). [The UniProt Consortium]