Anti-Alpha-Sarcoglycan (Adhalin), clone Ad1/20A6 (monoclonal) [Mouse]

Human alpha-sarcoglycan, also known as adhalin . Also cross reacts strongly with alpha-sarcoglycan in sections of muscle from mouse, rat, rabbit, hamster and pig. Does not react with chicken muscle. MONX10813 is recommended for use as part of a panel of antibodies in immunohistochemistry to direct genetic mutation analysis in the diagnosis and differentiation of the recessive muscular dystrophies. In particular, it can be used to identify alpha-sarcoglycanopathy (limb-girdle muscular dystrophy type 2D) and severe childhood autosomal recessive muscular dystrophy (SCARMD) where mutations in the alpha-sarcoglycan gene or defective expression of alpha-sarcoglycan can occur. Protein function: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. [The UniProt Consortium] Protein function: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. [The UniProt Consortium]