Anti-Alpha-conotoxin LvIA

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
CSB-PA926267XA01DWC.50	50 µl		-	-	10 - 14 business days*		167.00€
CSB-PA926267XA01DWC.100	100 µl		-	-	10 - 14 business days*		285.00€

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Protein function: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic... more

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Product information "Anti-Alpha-conotoxin LvIA"

Protein function: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks alpha-3-beta-2/CHRNA3-CHRNB2 nAChR with high selectivity (IC(50)=8.67 nM (on rat) and 17.5 (on human)) (PubMed:24398291). Has also weaker activity on alpha-6/alpha-3-beta-2- beta-3 (CHRNA6/CHRNA3-CHRNB2-CHRNB3) (IC(50)=108 nM (on rat)), alpha- 6/alpha-3-beta-4 (CHRNA6/CHRNA3-CHRNB4) (IC(50)=121 nM (on rat)), alpha-3-beta-4 (CHRNA3-CHRNB4) (IC(50)=148 nM (on rat)), and alpha- 7/CHRNA7 nAChRs (IC(50)=3000 nM (on rat)) (PubMed:24398291). When tested on mouse with hot-plate tests, this toxin significantly increases the base pain threshold and shows analgesic effects (PubMed:26742048). [The UniProt Consortium]

Keywords:	Anti-Alpha-CTx LvIA, Anti-Alpha-conotoxin LvIA, Alpha-conotoxin LvIA Antibody
Supplier:	Cusabio
Supplier-Nr:	PA926267XA01DWC

Properties

Application:	ELISA
Antibody Type:	Polyclonal
Conjugate:	No
Species reactivity:	Conus lividus
Immunogen:	Recombinant Conus lividus (Livid cone) Alpha-conotoxin LvIA protein (21-36aa)