Anti-ALDOC / Aldolase C

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. ALDOC antibody detects Aldolase C, a glycolytic enzyme involved in the reversible cleavage of fructose-1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate. Encoded by the ALDOC gene on chromosome 17q11.2, this protein is one of three aldolase isoenzymes (A, B, and C) expressed in a tissue-specific manner. Aldolase C is predominantly found in the brain and other neural tissues, where it supports both glycolytic energy metabolism and neuronal development.Structurally, Aldolase C functions as a homotetramer with catalytic lysine residues that form Schiff bases with its substrate. It shares high sequence identity with Aldolase A (muscle type) and B (liver type) but exhibits unique kinetic properties suited for neuronal metabolism. In neurons and glial cells, Aldolase C contributes to glucose utilization, energy coupling, and maintenance of synaptic function. It also interacts with cytoskeletal proteins, suggesting roles beyond metabolism, including regulation of actin organization and cell morphology.The ALDOC antibody is widely used in neuroscience, metabolism, and cell biology research to study glycolytic regulation and neural differentiation. Western blot analysis identifies a 39 kilodalton band corresponding to Aldolase C, while immunohistochemistry reveals strong cytoplasmic staining in Purkinje cells and astrocytes. This antibody supports investigation of metabolic compartmentalization and energy flux in the central nervous system.Altered expression of Aldolase C has been observed in neurodegenerative diseases and gliomas, where metabolic reprogramming contributes to pathogenesis. Beyond the brain, ALDOC expression in epithelial and endocrine tissues suggests additional roles in energy balance and biosynthesis. The ALDOC antibody provides a reliable reagent for analyzing glycolytic enzyme distribution and function. NSJ Bioreagents offers this antibody validated for its applications, ensuring high specificity and reproducibility for metabolic and neurobiological studies.