Anti-AKAP8L/HA95 (IHC)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00277-T 10 µl (5+ slides) -

3 - 9 business days

125.00€
IHC-00277 100 µl (50+ slides) -

3 - 9 business days

456.00€
 
Protein function: Could play a role in constitutive transport element (CTE)-mediated gene... more
Product information "Anti-AKAP8L/HA95 (IHC)"
Protein function: Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3, in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903). [The UniProt Consortium]
Keywords: Anti-HA95, Anti-HAP95, Anti-NAKAP, Anti-AKAP8L, Anti-HRIHFB2018, Anti-Neighbor of AKAP95, Anti-AKAP8-like protein, Anti-Homologous to AKAP95 protein, Anti-Helicase A-binding protein 95, Anti-A-kinase anchor protein 8-like
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00277-T

Properties

Application: IHC, IHC-IF
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human (Expected: Gorilla, Chimpanzee, Chinese Hamster, Naked Mole Rat, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00277 maps to a region between residue 596 and 646 of human A kinase (PRKA) anchor protein 8-like (helicase A-binding protein 95 kDa) using the numbering given in entry NP_055186.2 (GeneID 26993).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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