Anti-AIF1 / IBA1, clone 31A74

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. IBA1 antibody detects allograft inflammatory factor 1 (AIF1), a calcium-binding protein expressed in microglia and macrophages. IBA1 participates in actin cytoskeleton remodeling, enabling immune cells to migrate and phagocytose effectively. In the central nervous system, it serves as a widely used microglial marker, allowing researchers to monitor immune responses within brain tissue. Its expression increases during neuroinflammation, making it valuable for studying disease-related activation states.Applications of IBA1 antibody include research on Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury. Microglial activation visualized through IBA1 staining helps define the extent and nature of neuroimmune involvement in these conditions. Beyond neuroscience, AIF1 is also expressed in peripheral macrophages, where it regulates inflammatory pathways and vascular remodeling, linking it to atherosclerosis and transplant rejection models.Antibodies against IBA1 are validated for immunohistochemistry, immunofluorescence, and western blot. These tools allow precise localization of microglia and provide insights into how immune cells interact with neurons and glia in health and disease. Clone-based products ensure high specificity with minimal background staining.NSJ Bioreagents provides this IBA1 antibody for research applications in neuroscience, inflammation, and immunology. Alternate names include allograft inflammatory factor 1 antibody, ionized calcium-binding adapter molecule 1 antibody, and microglial marker antibody.