Anti-AGO3 / Argonaute-3 / eIF2C3, clone GGF-1

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. AGO3 antibody targets Argonaute-3 (AGO3), a member of the Argonaute family of RNA-binding proteins that function in RNA-mediated gene silencing. AGO3 is a core component of the RNA-induced silencing complex, where it associates with small RNAs to regulate post-transcriptional gene expression. The protein localizes predominantly to the cytoplasm, with enrichment in RNA granules such as processing bodies, reflecting its role in messenger RNA stability, translational repression, and RNA turnover. This reagent is a recombinant rabbit monoclonal antibody, providing defined specificity and lot-to-lot consistency for research use.Functionally, AGO3 binds small regulatory RNAs and participates in sequence-guided recognition of target transcripts. Through these interactions, AGO3 contributes to fine-tuning gene expression programs involved in differentiation, stress responses, and maintenance of cellular homeostasis. While some Argonaute family members show specialized catalytic activity, AGO3 supports the broader RNA interference machinery and complements other Argonaute proteins to ensure robust post-transcriptional regulation. An AGO3 antibody supports studies examining RNA silencing pathways and RNA-protein interactions.AGO3 expression is observed across multiple tissues and cell types, consistent with the widespread requirement for RNA-based gene regulation in eukaryotic cells. Its cytoplasmic localization and association with RNA granules provide insight into the organization and dynamics of RNA interference complexes. Analysis of AGO3 abundance and distribution helps clarify how small RNA pathways integrate into cellular regulatory networks.From a biological and disease-relevance perspective, Argonaute proteins are widely studied in development, cancer biology, and neurological research due to their central roles in gene regulatory control. Dysregulation of RNA silencing machinery can alter cellular identity and contribute to disease-associated transcriptional changes. AGO3 therefore represents an important component of post-transcriptional control systems that shape cellular behavior under physiological and pathological conditions.At the molecular level, AGO3 is encoded by the AGO3 gene and produces a protein of approximately 860 amino acids containing conserved PAZ and PIWI domains required for small RNA binding and target interaction. Regulation of AGO3 function depends on RNA availability, protein-protein interactions, and cellular context. An AGO3 antibody supports research applications focused on RNA interference, post-transcriptional gene regulation, and RNA biology, with NSJ Bioreagents providing reagents intended for research use.Explore our AGO3 Antibody - Argonaute RNA Silencing and RISC Complex Marker (PCRP-AGO3-1C5) page for a broader view of AGO3 expression and RNA interference biology.