Anti-AGO3 (Argonaute-3) / eIF2C3, clone PCRP-AGO3-1C5

Formulation: Purified Ab with BSA and Azide at 200ug/ml. Cellular Localization: Cytoplasm, P-body. Positive Control: HeLa, MCF7 or U-2OS cells. Chromosome Location: 1p34.3. Protein Function: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (PubMed:29040713) [The Uniprot Consortium]