Anti-ADAM 23 (A Disintegrin And Metalloproteinase 23)

Anti-ADAM 23 (A Disintegrin And Metalloproteinase 23)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A0859-41D.100 100 µg - -

3 - 19 business days*

916.00€
 
ADAM23 (a disintegrin and metalloprotease domain 23, also MDC3) is a 100kD member of the M12B... more
Product information "Anti-ADAM 23 (A Disintegrin And Metalloproteinase 23)"
ADAM23 (a disintegrin and metalloprotease domain 23, also MDC3) is a 100kD member of the M12B peptidase family of enzymes. It is expressed on fetal neurons in the hippocampus and cerebellum, and serves as a counter-receptor for alpha v beta 3 integrin. The human ADAM23 proprecursor is a 773aa type I transmembrane (TM) protein. It contains a 227aa cleavable proregion (aa60-286) and a 506aa extracellular domain (ECD) (aa287-792) that is part of a 70kD mature molecule. The ECD contains a nonfunctional metalloprotease domain (aa299-494), an integrin-binding disintegrin region (aa511-585), and a Cys-rich domain (aa589-611). Two splice variants exist. One shows an in-frame 46aa substitution for aa787-832 that generates a soluble form, while a second shows an in-frame 31aaTM substitution for aa787-817. Over aa1-585, human ADAM23 is 92% aa identical to mouse ADAM23. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 25ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Anti-MDC3, Anti-MDC-3, Anti-ADAM23, Anti-Disintegrin and metalloproteinase domain-containing protein 23, Anti-Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3
Supplier: United States Biological
Supplier-Nr: A0859-41D

Properties

Application: IHC
Antibody Type: Monoclonal
Clone: 9H37
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: CHO-derived, recombinant human ADAM23 aa1-585, O75077.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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