Anti-ADA / Adenosine deaminase

Anti-ADA / Adenosine deaminase
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R32414 100 µg - -

3 - 10 business days*

549.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Adenosine deaminase (also known as... more
Product information "Anti-ADA / Adenosine deaminase"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Adenosine deaminase (also known as adenosine aminohydrolase, or ADA) is an enzyme involved in purine metabolism. Primarily, ADA in humans is involved in the development and maintenance of the immune system. However, ADA association has also been observed with epithelial cell differentiation, neurotransmission, and gestation maintenance. It has also been proposed that ADA, in addition to adenosine breakdown, stimulates release of excitatory amino acids and is necessary to the coupling of A1 adenosine receptors and heterotrimeric G proteins. Adenosine deaminase deficiency leads to pulmonary fibrosis, suggesting that chronic exposure to high levels of adenosine can exacerbate inflammation responses rather than suppressing them. It has also been recognized that adenosine deaminase protein and activity is upregulated in mouse hearts that overexpress HIF-1 alpha, which in part explains the attenuated levels of adenosine in HIF-1 alpha expressing hearts during ischemic stress. Protein function: Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte- epithelial cell adhesion. [The UniProt Consortium]
Keywords: Anti-ADA, Anti-ADA1, EC=3.5.4.4, Anti-Adenosine deaminase, Anti-Adenosine aminohydrolase, ADA Antibody / Adenosine deaminase
Supplier: NSJ Bioreagents
Supplier-Nr: R32414

Properties

Application: WB, IHC (paraffin)
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Amino acids Q135-L363 of the human protein were used as the immunogen for the Adenosine deaminase antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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