Anti-ACTH / POMC (recombinant antibody), clone r57

Anti-ACTH / POMC (recombinant antibody), clone r57
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3466-20UG 20 µg - -

3 - 10 business days*

332.00€
NSJ-V3466-100UG 100 µg - -

3 - 10 business days*

752.00€
 
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. ACTH (same as... more
Product information "Anti-ACTH / POMC (recombinant antibody), clone r57"
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This mAb is specific to Synacthen (aa1-24 of ACTH), does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH. Protein function: Corticotropin: Stimulates the adrenal glands to release cortisol. [The UniProt Consortium]
Keywords: Anti-POMC, Recombinant ACTH Antibody / POMC
Supplier: NSJ Bioreagents
Supplier-Nr: V3466

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: r57
Conjugate: No
Host: Mouse
Species reactivity: human, mouse, rat (Expected: broad)
Immunogen: An N-terminal peptide (within AA 1-24) from the Synacthen/ACTH region of human POMC was used as the immunogen for this recombinant ACTH antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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