Anti-ACTA2 / Alpha Actin / Smooth Muscle Actin, clone ACTA2/13673R

1 mg/ml in 1X PBS, BSA free, sodium azide free. Alpha-SMA antibody, also known as Myofibroblast Marker antibody, recognizes Alpha smooth muscle actin, a contractile cytoskeletal protein encoded by the human ACTA2 gene located on chromosome 10q23.31. Alpha smooth muscle actin, frequently abbreviated as alpha-SMA, is predominantly localized to the cytoplasm where it polymerizes into actin filaments that contribute to cellular contractility and structural support. Alpha-SMA antibody targets a protein widely used as a marker of smooth muscle cells and activated myofibroblasts in normal and diseased tissues.ACTA2 belongs to the alpha actin subfamily within the conserved actin protein family. In normal physiology, Alpha smooth muscle actin is strongly expressed in vascular smooth muscle cells, uterine myometrium, and other contractile tissues, where it interacts with myosin to generate force and regulate vascular tone. During wound healing and tissue repair, fibroblasts can differentiate into myofibroblasts characterized by increased ACTA2 expression and acquisition of contractile properties. These myofibroblasts play essential roles in extracellular matrix remodeling and wound contraction.As a Myofibroblast Marker antibody, alpha-SMA is frequently used in studies of fibrosis, tumor stroma, and chronic inflammatory conditions. Increased ACTA2 expression is observed in fibrotic diseases of the lung, liver, kidney, and heart, where persistent myofibroblast activation contributes to excessive matrix deposition and tissue stiffening. In cancer biology, alpha-SMA-positive cancer-associated fibroblasts are prominent components of the tumor microenvironment and influence tumor growth, invasion, and therapeutic response. Because of its consistent enrichment in activated stromal cells, Alpha-SMA antibody is a valuable tool for evaluating stromal activation and tissue remodeling.Alpha-SMA antibody is suitable for detecting ACTA2 expression in research focused on fibrosis, vascular biology, wound healing, and tumor microenvironment analysis. Recombinant monoclonal clone ACTA2/13673R is produced using defined expression systems to promote lot-to-lot consistency and reliable performance in research applications.