Anti-ACE2 / Angiotensin-converting enzyme 2, clone MSVA-919R

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. Angiotensin-converting enzyme 2 (ACE2) is a membrane-associated metalloprotease encoded by the ACE2 gene that functions as a key regulator of the renin-angiotensin system. ACE2 Antibody for IHC is used to visualize the tissue distribution and cellular localization of Angiotensin-converting enzyme 2 within formalin-fixed paraffin-embedded specimens using immunohistochemistry. ACE2, also referred to as ACE2 receptor or Angiotensin-converting enzyme homolog, is widely expressed in epithelial tissues where it participates in the enzymatic conversion of angiotensin II to angiotensin-(1-7), a signaling pathway associated with vasodilatory and anti-inflammatory effects. Because of its physiological importance in cardiovascular, pulmonary, and epithelial biology, ACE2 expression patterns have been extensively studied in histological tissue sections.Immunohistochemistry studies commonly show ACE2 staining in epithelial cells of several organs including intestine, kidney, lung, and glandular tissues. Within these tissues, ACE2 protein is typically detected along cell membranes and within the cytoplasm of epithelial cells, consistent with its role as a membrane-associated enzyme involved in peptide processing and receptor-mediated signaling. Visualization of ACE2 expression in histological sections allows researchers to examine epithelial distribution patterns while preserving tissue architecture, enabling comparison of expression between different organs and between normal and disease-associated tissues.Large-scale immunohistochemistry studies frequently utilize human tissue microarray (TMA) platforms to evaluate ACE2 expression across diverse tissues in a standardized format. In human tissue microarray panels containing multiple normal and cancer tissues, ACE2 staining is typically strongest in epithelial compartments while stromal and connective tissues often display minimal signal. This epithelial-biased staining pattern has been consistently reported in public expression datasets and immunohistochemistry studies, supporting the use of tissue microarrays as an efficient method for assessing ACE2 distribution across many tissue types within a single experiment.A recombinant rabbit monoclonal antibody, clone MSVA-919R, recognizes ACE2 protein and is suitable for immunohistochemical analysis of ACE2 expression in human tissues. When applied to FFPE tissue sections and human tissue microarray (TMA) panels, this ACE2 Antibody for IHC highlights epithelial cell populations in multiple organs, enabling visualization of ACE2-positive cells within their histological context. These staining patterns align with published ACE2 expression profiles and with large-scale protein expression datasets such as the Human Protein Atlas, supporting the use of immunohistochemistry for studying ACE2 tissue distribution and epithelial expression patterns in normal and cancer tissues.This antibody is also part of a broader collection of IHC antibodies validated by tissue microarray analysis, supporting consistent staining across normal and cancer tissues.