Anti-ACCN4 / ASIC4

In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. Alternative splicing at this locus results in two transcript variants encoding different isoforms. Protein function: Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity. [The UniProt Consortium]