Anti-ABI1 (IHC)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
IHC-00240-T	10 µl (2500 ng)		-		2 - 8 business days*		178.00€
IHC-00240	100 µl (25 µg)		-		2 - 8 business days*		668.00€

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Protein function: May act in negative regulation of cell growth and transformation by interacting... more

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Product information "Anti-ABI1 (IHC)"

Protein function: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. [The UniProt Consortium]

Keywords:	Anti-e3B1, Anti-Abi-1, Anti-AblBP4, Anti-Nap1BP, Anti-SSH3BP1, Anti-Abl interactor 1, Anti-Abelson interactor 1, Anti-Eps8-binding protein, Anti-Nap1-binding protein, Anti-Abl-binding protein 4, Anti-Eps8 SH3 domain-binding protein
Supplier:	Bethyl Laboratories
Supplier-Nr:	IHC-00240

Properties

Application:	IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: mouse, rat, chicken, turkey, horse, rabbit, guinea pig, swine, panda, orangutan, rhesus monkey, gorilla, chimpanzee, duckbill platypus, tasmanian devil, white-tufted-ear marmoset, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by IHC-00240 maps to a region between residue 325 and 375 of human abl-interactor 1 using the numbering given in entry NP_005461.2 (GeneID 10006).
Format:	Antigen Affinity Purified