Anti-ABCG2 (BCRP)

0.5mg/ml if reconstituted with 0.2ml sterile DI water. ATP-binding cassette, subfamily g, member 2, also known as ABCP, BCRP or MRX,is aprotein that in humans is encoded by the ABCG2gene. Thegene encodes a membrane transporter belonging to the ATP-binding cassette(ABC) superfamily of membrane transporters, which are involved in the trafficking of biologic molecules across cell membranes.Theprotein is also a high capacity transporter for uric acid excretion in the kidney, liver, and gut. The ABCG2 gene is mapped on 4q22.1. In vitro assays of isolated membrane preparations revealed a high-capacity, vanadate-sensitive ATPase activity associated withABCG2expression that was stimulated by compounds known to be transported by this protein. Ozvegy et al.(2001)concluded thatthe proteinis likely functioning as a homodimer or homooligomer in this expression system since it is unlikely that putative Sf9 transport partners would be overexpressed at similarly high levels.Abcg2transports pheophorbide-a, which occurs in various plant-derived foods and food supplements and is highly efficient in limiting its uptake from ingested food.ABCG2is a major factor in the concentrative transfer of drugs, carcinogens, and dietary toxins to the milk of mice, cows, and humans. Protein function: High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin. [The UniProt Consortium]