Anti-ABCB5, clone CL14064

Monoclonal Antibody against Human MSH3, Clone ID: CL14064, Gene description: Muts homolog 3, Alternative Gene Names: DUP, MRP1, Validated applications: ICC, IHC, WB, Uniprot ID: P20585, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein function: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. [The UniProt Consortium] Mouse gene identity: 100% Rat gene identity: 100%