Anti-AAT1

alternative products:Additional isoforms (AAT-1L and AAT-1S) may exist,function:Isoform 4 may play a role in spermatogenesis.,PTM:Isoform 4 is phosphorylated by PKA.,subcellular location:Isoform 4 is found in the mitochondria and localized in the neck of the sperm.,subunit:Interacts with AMY1 and AKAP1. Isoform 4 belongs to a complex together with AMY1, AKAP1 and PRKAR2B. Isoform 3 does not interact with AMY1.,tissue specificity:Isoform 1 is strongly expressed in the liver. Isoform 4 is widely expressed, but strongly expressed in all spermatogenesis-related tissues, including the testis, the epithelium of cauda and the corpus epididymis. Isoform 4 is present in the spermatid and mature sperm. Isoform 4 is also expressed in Leydig cells. Isoform 3 is expressed in the testis., Protein function: Involved in sperm flagellum axonemal organization and function (PubMed:12223483, PubMed:32161152). May regulate cilium motility through its role in the assembly of the axonemal radial spokes. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: Mitochondrion . Cytoplasm . Cytoplasm, cytoskeleton, cilium axoneme . Localized in the neck of the sperm., [Isoform 7]: Cytoplasm .