Anti-8-hydroxy Guanosine (Clone 7E6)

8-Hydroxy-2'-deoxyguanosine (8-OH-dG, Cay-89320) and 8-hydroxyguanosine (8-OHG, Cay-89300) are oxidized nucleosides and markers of DNA and RNA oxidative damage, respectively. Levels of 8-OH-dG increase in DNA in the presence of eugenol and hydrogen peroxide or copper sulfate. Levels of 8-OHG increase in response to hydrogen peroxide in HeLa cells in a concentration-dependent manner. 8-OHG has been detected in neurons in postmortem brain from patients with Alzheimer's or Parkinson's disease. Cayman's DNA/RNA Oxidative Damage Monoclonal Antibody (Clone 7E6) can be used for affinity purification and ELISA applications.Synonyms: 8-OH-dG, 8-OHG, 8-oxo-G, 7,8-dihydro-8-oxoguanosine. Immunogen: 8-Hydroxy-2-deoxyguanosine. Clone Designation: 7E6. Formulation: (Request formulation change), 100 µg of ammonium sulfate purified IgG. Storage Buffer: PBS, pH 7.2, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide. Host: Mouse. Isotype: IgG1. Applications: ELISA and IP. Cross Reactivity: (+) 8-hydroxy-2-deoxyguanosine, (+) 8-hydroxy Guanosine.